Anthemius was born in Galatia, and came from a wealthy and distinguished and highly influential family in the eastern empire, a recent ancestor of his, Procopius, having been declared Augustus at Constnatinople in the brief rebellion against Valen's rule in AD 365, and his father, also called Procopius, being of patrician rank and having held the post of 'Master of Soldiers'. His maternal grandfather Anthemius was praetorian prefect and had acted as regent while Theodosius II was still a child.
Anthemius himself held military command in Thrace in AD 453-4, and became 'Master of Soldiers' in 454-67. He also was appointed consul and granted the rank of patrician (patricius) in AD 455.
At Marcian's death, Anthemius was even understood to be the most likely man to succeed him to the throne of the eastern empire, accept that Aspar, the powerful 'Master of Soldiers', preferred to see one of his own men on the throne. Hence the choice fell upon Leo instead.
Anthemius though was not the kind of man to hold a grudge against Leo and went on to serve him well, winning military victories for his emperor - first against the Ostrogoths in Illyricum from AD 459-464 and then against the Huns at Serdica (Sofia) in AD 466/7.
With the western throne having fallen vacant with the death of Libius Severus in November AD 465, and the Vandals proposing Olybrius as their candidate, Leo now saw it necessary to invest his own candidate. If only to prevent a western ruler with allegiances toward the Vandals. Also, a Vandal raid in AD 467 on the Peloponnese in Greece drove home to Leo just how great the threat posed by these barbarians had become.
With Anthemius having shown such loyal service and being of distinguished descent, he was the ideal candidate. So, in AD 467 Leo nominated Anthemius as western emperor.
Anthemius, aware of Ricimer's power in the west, first allied himself with him, by marrying his daughter Alypia to him.
Anthemius being a champion of the east, he brought about the end of the hostilities between the eastern and western empire. And both empires soon after embarked on another giant effort to overcome the Vandals. A massive fleet was assembled to carry the troops to their destinations. But the commanders were badly chosen. Basiliscus, who commanded the eastern fleet, was notoriously unreliable. Meanwhile the choice of Marcellinus as the commander of the western fleet, no doubt angered Ricimer, as he was Ricimer's foremost enemy.
Marcellinus successfully attacked Sardinia and landed troops in Tripolitania.
Then in Gaul a new threat arose as Euric murdered his brother Theodoric II and took over the ruel of the Visigoths, and set out on an attempt to bring entire Gaul under his control.
After this setback, relations between Anthemius and Ricimer deteriorated sharply. For Ricimer obviously wanted to rid himself of yet another unsuccessful emperor and Anthemius well knew that Ricimer's past record proved that an emperor had good reason to be suspicious of Ricimer.
In AD 470 the bishop of Ticinum (Pavia) managed to reconcile them, but the peace was not to last for long.
Anthemius disguised himself as a beggar in an attempt to flee. But he was betrayed and by order of Ricimer's nephew Gundobad Anthemius was beheaded in March or April AD 472.